Knowledge on Medicines – Fexofenadine - Nepal Medicos Times
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Knowledge on Medicines – Fexofenadine

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Fexofenadine is an antihistamine used to relieve allergic symptoms such as tears, runny nose, itchy eyes, sneezing, urticaria and general itching. The mechanism of action of Fexofenadine is to block the naturally occurring histamine of the body during an allergic reaction.

How to use Fexofenadine?

If you purchase this product on your own, read all instructions on the packaging before using it. Ask your pharmacist if you have any questions. If your doctor prescribes Fexofenadine, follow the instructions, usually 2 times a day.
If you use a liquid medicine with a Fexofenadine, shake the bottle well before use and take the dose carefully with a special measuring instrument or spoon. Do not use a household spoon as it may not be possible to get the correct dose. This tablet, capsule or soluble medicine can be used with food.
If you use a fast-soluble tablet, take it on an empty stomach and let it be dissolved on your tongue and swallowed. When taking medicine with drinking liquids, you should choose water. Do not take with juices such as apples, grapefruit or orange, as these juices reduce the absorption of the drug. Recommended dosage varies based on age, condition, and response to treatment. Do not increase the dose arbitrarily or exceed the number of times indicated by your doctor. Do not take acids containing aluminum and magnesium for 2 hours after using this drug. Such acidulants reduce the absorption of the drug.

How to store Fexofenadine?

It is best to store the Fexofenadine at room temperature, away from direct sunlight and humidity. To avoid damage to the drug, the drug should not be stored in the bathroom or in a freezer. Different brands of Fexofenadine may be stored in different ways. It is important to confirm that instructions on storage on the package, or to confirm with the pharmacist how to store them. For safety purposes, all medications should be kept away from children and pets.
Flushing sensitive membrane coated ingots should not be flushed into the toilet or poured into the sink unless instructed to do so. When the drug expires or is no longer needed, it is important to dispose of the product properly. For further information about the safe disposal of this product, please contact your pharmacist.

Precautions and contraindications to the use of Fexofenadine

Before using Fexofenadine:
If you are Fexofenadine of the Fexofenadine, any medication, or any of the FHR tablets, please ask your pharmacist for a list of the ingredients of this medicine.
Inform your physician of all prescription, non-prescription, vitamins, nutritional supplements, and herbal products that are currently in use or are planned for use. Be sure to inform your doctor if you have any of the following drugs: Erythromycin, E-mycin, erythromycin, capsules, erythrocin and Ketoconazole. The doctor may correct the dosage of the drug and track if there are side effects.
If you are using acids containing, like aluminum or magnesium, you should take Fexofenadine a few hours after you are using the acid containing pills.
If you have kidney disease or have had kidney disease, you should inform your doctor.
Tell your doctor if you are pregnant, are planning to be pregnant, or are breastfeeding. Notify your doctor if you are pregnant during the use of Fexofenadine.

Is it safe to use Fexofenadine during pregnancy or lactation?

There is no suitable study on the risk of using Fexofenadine during pregnancy or lactation. Consult your doctor to measure the potential benefits and risks of using Fexofenadine. According to the U.S. Food and Drug Administration (FDA), the risk of pregnancy is classified as Class C.
The US FDA pregnancy risk classification is as follows:
A= no risk;
B= Some studies show no risk;
C = may be at risk;
D = evidence of risk;
X = contraindications;

Potential side effects of using Fexofenadine

Urgent medical assistance is required for the following allergic reactions: urticaria, dyspnea, swollen face, lips, tongue or throat. If you have fever, chills, body pain, cough, or cold symptoms, discontinue use of FHF and notify your doctor.
Lighter side effects may include nausea, diarrhea, stomach pain, menstrual cramps, dizziness, fatigue, headache, or muscle or back pain. Not all will experience the side effects described above. There may be some side effects not listed. If you have any concerns about side effects, please consult your doctor or pharmacist.

Potential interaction with Fexofenadine

What medications may interact with Fexofenadine?
Fexofenadine may interact with your current drug and change the mechanism of action or increase the risk of serious side effects. To avoid potential drug interactions, you should list and inform physicians and pharmacists of the drugs currently in use, including prescription, non-prescription, and herbal products. For your safety, do not start, stop, or change the dosage of any medication without your doctor’s consent.
Fexofenadine are generally not recommended for use with any of the following drugs:
  • Eliglustat – An oral pill for treatment of a rare disease, Gaucher’s disease
  • Lomitapide
  • Nilotinib – Drugs for the treatment of chronic myeloid leukemia
  • Simeprevir
  • Tocophersolan

However, there may still be a need. If the prescription contains both drugs, the doctor may change the dose or frequency of use of one or both drugs, or both may be adjusted.
The combination of the following drugs may increase the risk of certain side effects when using Fexofenadine, but using both drugs is the best treatment for you. If you prescribe 2 medications simultaneously, your doctor may change the dose or frequency of use of one drug, or both drugs may be adjusted.
  • Aluminum Carbonate
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Magaldrate
  • Magnesium Carbonate
  • Magnesium Hydroxide
  • Magnesium Oxide
  • Magnesium Trisilicate

Does food or alcohol interact with Fexofenadine?

By changing the mechanism of action of the drug, Fexofenadine can interact with food or alcohol or increase the risk of serious side effects. Please discuss with your doctor or pharmacist any foods or alcohol that may cause potential interactions before using this drug.
Apple juice
Grapefruit juice
Orange juice

What sickness will interact with Fexofenadine?

Fexofenadine may interact with health conditions. Such interactions can worsen your health or change the mechanism of action of the drug. It is important for physicians and pharmacists to know your current state of health, in particular:
Kidney disease – Use with caution. Because kidney disease slows down the time it takes to remove the drug, the efficacy may increase.
Phenylketonuria – Use with care. Oral drugs may contain phenylalanine.

Recommended Dosage for Fexofenadine

The information provided here is not an alternative to any medical advice. Consult your doctor or pharmacist before using the drug.

Recommended dosage for general adults:

  • Recommended dosage for allergic rhinitis: 60 mg (mg) twice daily, or 180 mg once daily with water.
  • Recommended dose for urticaria: 60 mg twice daily, or 180 mg once daily with water.
What is the recommended amount for children?

  • Recommended dosage for allergic rhinitis:Oral tablets: Children aged 6 to 11 years: 30 mg twice daily with water; children over 12 years old: 60 mg twice daily; or 180 mg once daily with water.
  • Oral Tablets: Children 6 to 11 years old: 30 mg twice daily.
  • Oral suspension: Children aged 2 to 11 years 30 mg twice daily with water.
  • Recommended dosage for urticaria:Oral tablets: Children aged 6 to 11 years: 30 mg twice daily with water; children over 12 years old: 60 mg twice daily; or 180 mg once daily with water.
  • Oral solution: Children aged 6 to 11 years: 30 mg twice daily.
  • Oral suspension: chronic autopsy urticaria: 6 months ~ 1 year: 15 mg twice daily; children aged 2 to 11 years: 30 mg twice daily.

What types of manufactured products are available for Fexofenadine?

The following manufactured product types and doses are available:
Hydrochloride oral suspension: 30 mg/5 ml (120 ml).
Oral tablets of hydrochloric acid: 30 mg, 60 mg, 180 mg.
Tablet Dispersible Hydrochloride: 30 mg.

What should I do if there is an emergency or overdose?

In case of any emergency or overdose, call an ambulance or visit the nearest emergency room.

What should I do if I miss a dose?

If you miss a dose, fill it up as soon as possible. However, if you are close to the next medication, skip the missed time and use the original table that you should eat. Do not use twice the dose.